In our initial testing, even FXL directly from InDesign (CC 2015) worked flawlessly. Cloudself is a program to keep the eye on. Perhaps the future ereading projects may find this platform as an interesting option to recommend and even build on.
Link to Appstore:
Readium is an OpenSource Tech for EPUB 3 and the Open Web platform. Initiated by IDPF and architected to work on any modern (HTML5) browser.
Bluefire is a maker of Bluefire reader (iOS, Android, Windows) one of the most popular eReaders capable of handling Adobe DRM